Hereditary. Certain enzymes are required for the body to be able to balance storage and breakdown of fats. Any Imbalances or abnormal production of these enzymes can lead to an accumulation of fats that can damage many organs in the body
WGaucher's disease is the most common type of lipid storage disease. It is by caused by a deficiency of an enzyme called glucocerebrosidase. In this inherited disease fat collects in the brain, lungs, liver, spleen, kidneys and bone marrow. This causes the organs to enlarge, swell and malfunction as well as bone disorders and painful lesions.
Metabolic disorders , Lipid oxidation disorders are caused by a deficiency or lack of the enzymes needed to break down fats to produce energy. This decreases energy in the body and leads to delayed physical and mental development, according to the National Institute of Neurological Disorders and Stroke.
While we can go on analysing all the methods of Cholestrol accumulation in the body, Ayurveda explains our body is made up of 5 elements and so are all the things that we eat. Cholestrol as per Ayurveda is simply a result of improper digestive fire.
Jatharaghni is responsible for digestion. While Bhutagni transfers the energy from the food you eat to your body to support the panchamahabutas in your system. Dhatvagni refers to tissue metabolism. According to Ayurveda, our body is made up of seven dhatus- Rasa (Body fluids like lymph), Rakta (Blood and its components), Mamsa (Muscular system), Meda (adipose or fat tissue), Asthi (Skeletal system), Majja( Bone marrow) and ShukraDhatu (reproductive system). The nutrients absorbed from the intestine is processed in each of these system by respective dhatvagnis for their nourishment, proper functioning and development. When the body to be in a Dosha free state, the Agni that is there is Samaghni.